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Feruloylated oligosaccharides from maize bran alleviates the symptom of diabetes in streptozotocin-induced type 2 diabetic rats

Abstract

This study investigated the therapeutic effect of feruloylated oligosaccharides (FOs) extracted from maize bran on type 2 diabetic rats and its potential mechanism. Streptozotocin (STZ) induced type 2 diabetic male rats were orally administrated with different levels of FOs for 8 weeks, and ferulic acid (FA) treatment was conducted as positive control. Among all the treatments, oral administration of 600 mg/kg bw/d FOs showed best therapeutic effects on the diabetic rats by significantly lowering the levels of fast plasma glucose (FPG), fast insulin, TG, LDL-c, aspartate transaminase, creatine kinase and lactate dehydrogenase in plasma, while increasing the level of plasma HDL-c. In addition, intake of FOs at 600 mg/kg bw/d exhibited the best antioxidant effects in plasma, liver, kidney and heart of the diabetic rats, and the highest inhibitory effects on the formation of AGEs and CML in the organs, which might explain the alleviating effects of FOs on abdominal aorta injury observed in the current study. FOs presented better regulation effects on FPG, plasma lipid and the protection of abdominal aorta when compared with FA under the same administrated dosage. Based on these outcomes, FOs from maize bran could be beneficial for prevention or early treatment of diabetes mellitus.

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Publication details

The article was received on 18 Nov 2017, accepted on 07 Feb 2018 and first published on 07 Feb 2018


Article type: Paper
DOI: 10.1039/C7FO01825H
Citation: Food Funct., 2018, Accepted Manuscript
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    Feruloylated oligosaccharides from maize bran alleviates the symptom of diabetes in streptozotocin-induced type 2 diabetic rats

    J. Huang, X. Wang, G. Tao, Y. Song, C. Ho, J. Zheng and S. Ou, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01825H

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