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Effects of a combined intervention with lentil protein hydrolysate and a mixed training protocol on lipid metabolism and hepatic markers of NAFLD in Zucker rats.

Abstract

Metabolic syndrome is a cluster of metabolic alterations characterized by central obesity, dyslipidemia, elevated plasma glucose, insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). In this study, a combined intervention of lentil protein hydrolysate and a mixed training protocol was assessed in an animal experimental model of genetic obesity and metabolic syndrome. Thirty-two male obese and 32 lean Zucker rats were allocated to eight different experimental groups. Rats performed a mixed exercise protocol or had a sedentary lifestyle and were administrated a lentil protein hydrolysate or placebo. Daily food intake, weekly body weight gain, plasma parameters of glucose and lipid metabolism, body composition, hepatic weight, total fat content and fatty acid profile, as well as gene expression of lipogenic and lipolytic nuclear transcription factors and their target genes were measured. Obese Zucker rats exhibited higher body and liver weight and fat content compared to their lean counterparts. Such alterations were related to modifications in aerobic capacity, plasma biochemical parameters of glucose and lipid metabolism, hepatic fatty acid profile and gene expression of nuclear transcription factors SREBP1c, PPAR, LXR and associated lipogenic and lipolytic enzymes. The interventions tested did not affect body weight gain but improved the aerobic capacity, reduced hepatomegalia and steatosis associated to NAFLD and relieved the adverse effects produced by this condition in the glucose and lipid metabolism through the modulation in expression of different genes involved in diverse metabolic pathways.

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Publication details

The article was received on 13 Nov 2017, accepted on 03 Jan 2018 and first published on 04 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01790A
Citation: Food Funct., 2018, Accepted Manuscript
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    Effects of a combined intervention with lentil protein hydrolysate and a mixed training protocol on lipid metabolism and hepatic markers of NAFLD in Zucker rats.

    R. Martínez, G. Kapravelou, A. Donaire, C. López Chaves, F. Arrebola, M. Galisteo, S. Cantarero-Malagón, P. Aranda, J. M. M. Porres Foulquie and M. Lopez-Jurado, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01790A

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