Jump to main content
Jump to site search

Issue 1, 2018
Previous Article Next Article

An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice

Author affiliations

Abstract

Lignans are dietary polyphenols, which are metabolized by gut microbiota into the phytoestrogenic metabolites enterolignans, mainly enterolactone and enterodiol. Breast Cancer Resistance Protein (BCRP/ABCG2) is an efflux transporter that affects the plasma and milk secretion of several drugs and natural compounds. We hypothesized here that Abcg2 could influence the levels of lignans and their derived metabolites in target tissues. Consequently, we aimed to evaluate the role of Abcg2 in the tissue distribution of these compounds. We used Abcg2−/− knockout and wild-type male mice fed with a lignan-enriched diet for one week and analysed their plasma, small intestine, colon, liver, kidneys and testicles. High levels of lignans as well as enterolignans and their glucuronide and sulfate conjugates in the small intestine and colon were detected, with higher concentrations of the conjugates in the wild-type compared with Abcg2−/− mice. Particularly relevant was the detection of 24-fold and 8-fold higher concentrations of enterolactone-sulfate and enterolactone-glucuronide, respectively, in the kidney of Abcg2−/− compared with wild-type mice. In conclusion, our study showed that lignans and their derived metabolites were in vivo substrates of Abcg2, which affected their plasma and tissue levels. These results highlight the role of Abcg2 in influencing the health-beneficial properties of dietary lignans.

Graphical abstract: An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Oct 2017, accepted on 09 Dec 2017 and first published on 11 Dec 2017


Article type: Paper
DOI: 10.1039/C7FO01549F
Citation: Food Funct., 2018,9, 636-642
  •   Request permissions

    An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice

    D. García-Mateos, R. García-Villalba, J. A. Otero, J. A. Marañón, J. C. Espín, A. I. Álvarez and G. Merino, Food Funct., 2018, 9, 636
    DOI: 10.1039/C7FO01549F

Search articles by author

Spotlight

Advertisements