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Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats

Abstract

This study evaluated the protective effects of two rosemary components, namely, rosmarinic acid and carnosic acid against hypoglycemia, hyperlipidemia, oxidative stress and an imbalanced architecture of gut microbiota in diabetic rats. The treatment with rosmarinic acid and carnosic acid (30 mg/Kg) decreased the levels of fasting plasma glucose (23.7%, 15.6%), total cholesterol (30.4%, 14.1%), and triglyceride (65.7%, 47.8%) at 15 weeks. Rosmarinic acid and carnosic acid also exhibited antioxidative and anti-glycative effect by lowering the formation of MDA and advanced glycation end-products. In addition, they showed protective effects against tissue damage and inflammation in the abdominal aorta based on microscopic observation and the analysis of protein expression. Finally, their prebiotic effects on gut microbiota were demonstrated by increasing the population of diabetes-resistant bacteria and decreasing the amount of diabetes-sensitive bacteria. Overall, rosmarinic acid showed stronger protective effect than carnosic acid in mitigating the diabetic symptoms in rats.

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Publication details

The article was received on 28 Sep 2017, accepted on 03 Jan 2018 and first published on 12 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01508A
Citation: Food Funct., 2018, Accepted Manuscript
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    Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats

    J. Ou, J. Huang, D. Zhao, B. Du and M. Wang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01508A

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