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Rooibos tea extracts inhibit osteoclast formation and activity through attenuation of NF-κB activity in RAW264.7 murine macrophages

Abstract

Rooibos tea is a naturally sweet and aromatic tea that is native to the Western Cape province of South Africa. Rooibos is usually fermented to produce the traditional reddish brown colour and has been found to have numerous health benefits. These include beneficial effects on osteoblasts, however, its effects on osteoclast formation and activity is unknown. Osteoclasts are large, multinucleated cells responsible for bone resorption. Binding of RANKL to its receptor on osteoclast precursors triggers the NF-κB signalling pathway leading to the formation of osteoclasts. Certain bone destructive diseases, such as osteoporosis, are characterised by overactive osteoclasts. Inhibition of osteoclasts may offer a potential mode to prevent these diseases. The polyphenol content of both fermented and unfermented tea extracts were similar although the radical scavenging activity of fermented rooibos tea was lower. Both tea extracts were not cytotoxic and inhibited osteoclast formation. Fermented rooibos tea extract caused a greater reduction in the osteoclast resorption and associated gene expression when compared with unfermented rooibos tea. Both tea extracts were shown to attenuate NF-κB activity. Fermented rooibos was found to have a more potent inhibitory effect on osteoclasts than unfermented rooibos extract and therefore may have a beneficial effect on bone health.

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Publication details

The article was received on 26 Sep 2017, accepted on 29 Apr 2018 and first published on 02 May 2018


Article type: Paper
DOI: 10.1039/C7FO01497J
Citation: Food Funct., 2018, Accepted Manuscript
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    Rooibos tea extracts inhibit osteoclast formation and activity through attenuation of NF-κB activity in RAW264.7 murine macrophages

    S. Moosa, A. E. Kasonga, V. Deepak, S. Marais, I. B. Magoshi, M. J. Bester, M. C. Kruger and M. Coetzee, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01497J

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