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Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE

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Abstract

Alzheimer's disease (AD) is a global health issue affecting millions of elderly people worldwide. The aim of the present study was to identify novel anti-AD peptides isolated from albumin. Anti-AD activities of the peptides were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Furthermore, the potential molecular mechanisms of the KLPGF/AChE were investigated by CDOCKER of Discovery studio 2017. The results revealed that peptide KLPGF could effectively inhibit AChE with an inhibition rate of 61.23% at a concentration of 50 μg mL−1. In addition, the peptide KLPGF came in contact with acylation sites and peripheral anion sites of AChE. The present study demonstrates that the peptide KLPGF could become a potential functional food intervention in AD.

Graphical abstract: Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE

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Publication details

The article was received on 21 Sep 2017, accepted on 10 Jan 2018 and first published on 12 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01462G
Citation: Food Funct., 2018, Advance Article
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    Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE

    Z. Yu, S. Wu, W. Zhao, L. Ding, Y. Fan, D. Shiuan, J. Liu and F. Chen, Food Funct., 2018, Advance Article , DOI: 10.1039/C7FO01462G

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