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Anti-alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE

Abstract

Alzheimer’s disease (AD) is a global health issue affecting millions of elderly people worldwide. The aim of the present study was to identify novel anti-AD peptides isolated from the albumin. Anti-AD activities of the peptides were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Furthermore, the potential molecular mechanisms of the KLPGF / AChE were investigated by CDOCKER of Discovery studio 2017. Results revealed that peptide KLPGF could effectively inhibit AChE with an inhibition rate of 61.23% at a concentration of 50 μg/mL. And the peptide KLPGF contacted with acylation sites and peripheral anion sites of AChE. The present study demonstrated that the peptide KLPGF could become potential functional food intervention in AD.

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Publication details

The article was received on 21 Sep 2017, accepted on 10 Jan 2018 and first published on 12 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01462G
Citation: Food Funct., 2018, Accepted Manuscript
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    Anti-alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE

    Z. Yu, S. wu, W. zhao, L. ding, Y. FAN, D. shiuan , J. Liu and F. Chen, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01462G

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