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Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechins enriched Green and Oolong tea in a double-blind clinical trial

Abstract

This study was aimed to compare the beneficial effect of catechin-enriched green tea and Oolong tea on mildly hypercholesterolemic subjects. Sixty mild hypercholesterolemic subjects (180-220 mg/dL) were enrolled and divided into three groups as catechin-enriched green tea (CEGT), catechin-enriched oolong tea (CEOT) or placebo. Subjects were instructed to drink (2 x 300 mL) of CEGT (780.6 mg of catechin), CEOT (640.4 mg of catechin) or placebo beverage for 12 weeks. Drinking CEGT and CEOT significantly decreased (p < 0.05) the body weight, fat, and BMI, lipid peroxidation as well as lipid profile (TC, LDL-c, HDL-c, and TG). Also, intervention with CEGT and CEOT significantly improved (p < 0.05) the oxidative indices (TEAC, GSH) and antioxidant enzymes (SOD, CAT, GPx, GR). Moreover, ultrasound examination endorsed the hepatoprotective activity of CEGT and CEOT by reverting mild fatty liver to the normal hepatic condition because of antioxidant and hypolipidemic activities. To summarize, both CEGT and CEOT showed similar antioxidant and hepatoprotective activities. However, CEOT displayed superior lipid-lowering activity than CEGT or placebo, and hence it could be urged to amend the wellness condition of mildly hypercholesterolemic subjects.

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Publication details

The article was received on 19 Sep 2017, accepted on 09 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01449J
Citation: Food Funct., 2018, Accepted Manuscript
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    Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechins enriched Green and Oolong tea in a double-blind clinical trial

    K. Venkatakrishnan, H. Chiu, J. Cheng, Y. Chang, Y. Lu, Y. Han, Y. Shen, K. Tsai and C. K. Wang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01449J

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