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Structural characterization of two endopolysaccharides from Phellinus sp. and their immunologic effects by intragastric administration in a healthy mammalian model

Abstract

Two purified endopolysaccharides derived from cultured Phellinus sp., individually named as SHIP-1 and 2, were structurally characterized, along with an evaluation of their in vivo influential immunomodulatory activity in a healthy mammalian model. The structure of SHIP-1 was mainly composed of →4)-α-D-Fucp-(1→, →3,6)-α-D-Araf-(1→ and →2,4)-β-D-Galp-(→, with four residuals of α-D-Manp-(1→ and one α-D-Glcp-(1→ as sidegroups, while the planar structure and the heteronuclear multiple-bond correlation of SHIP-2 was not able to be analyzed. Biochemical analysis in the healthy mice model demonstrated that SHIP-1 increased concentrations of the detected cytokines in a dosage-dependent manner but not in a time dependent way. SHIP-2 exerted a positive effect in a dose-dependent manner over time for interferon gamma (IFN-γ) and interleukins (IL)-2 cytokine production at elevated dosages of 200, or 350 mg kg−1 d−1, while IFN-alpha(α) and IL-4 production was observed only in a dosage dependent manner even at high dosages. Thus, SHIP-1 and 2 significantly improved the immune response through intragastric administration of the tested high dosages by increasing the production of cytokines in the healthy mice, and these polysaccharides could be possibly used as an immunopotentiator in healthy foods or dietary supplement.

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Publication details

The article was received on 30 Jul 2017, accepted on 02 Jan 2018 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7FO01161J
Citation: Food Funct., 2018, Accepted Manuscript
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    Structural characterization of two endopolysaccharides from Phellinus sp. and their immunologic effects by intragastric administration in a healthy mammalian model

    X. Ma, Y. Ma, E. C. Peterson, W. Guo, Z. Li and Y. Li, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C7FO01161J

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