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How many ritonavir cases are there still out there?

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Abstract

Based on a thorough and critical analysis of the commercial crystal structure prediction studies of 41 pharmaceutical compounds, we conclude that for between 15 and 45% of all small-molecule drugs currently on the market the most stable experimentally observed polymorph is not the thermodynamically most stable crystal structure and that the appearance of the latter is kinetically hindered.

Graphical abstract: How many ritonavir cases are there still out there?

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Publication details

The article was received on 26 Mar 2018, accepted on 30 Apr 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8FD00069G
Citation: Faraday Discuss., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    How many ritonavir cases are there still out there?

    M. A. Neumann and J. van de Streek, Faraday Discuss., 2018, Advance Article , DOI: 10.1039/C8FD00069G

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