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Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles

Abstract

A series of triblock amphiphilic molecules, bearing hydrophilic PEG chains at the both ends of the long aromatic hydrophobic moieties were obtained serendipitously. The molecules involve linearly connected diarylethyne and diarylbutadiyne units, which show charcteristic emissions upon excitation by UV lights. These emissions showed red-shifts upon increase in the solvent polarity, where the shifts are larger for the molecules with longer aromatic moieties. Distribution of these molecules in the phase-separated membranes cosisting of DOPC/DPPC/cholesterol were studied by fluorescence microscopy. It was found that most compounds, except for that having the longest hyrdophobic unit, were seletcively distributed in Ld phase consiting mainly of DOPC. Interestingly, some of them were suggested to encourage delocalization of cholesterol in both Lo and Ld phases.

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Publication details

The article was received on 09 Feb 2018, accepted on 20 Mar 2018 and first published on 22 Mar 2018


Article type: Paper
DOI: 10.1039/C8FD00022K
Citation: Faraday Discuss., 2018, Accepted Manuscript
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    Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles

    K. Kinbara, K. Umetsu, H. Sonobe, T. Muraoka, N. Shimokawa and M. Takagi, Faraday Discuss., 2018, Accepted Manuscript , DOI: 10.1039/C8FD00022K

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