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Synthetic channel that efficiently inserts into mammalian cell membranes and destroys cancer cells

Abstract

Despite that a large number of synthetic channels have been developed in the last three decades, few of them can function in mammalian cell membranes because of their weak membrane-insertion abilities. This study describes that a tubular molecule with terminal positively charged amino groups displayed high ability of inserting into lipid bilayers composed of phosphatidylcholine and consequently forming unimolecular transmembrane channels. It has been demonstrated that the insertion of the channel into the phosphatidylcholine bilayers was driven by the electrostatic interaction between the positively charged amino groups of the channel molecules and the negatively charged phosphate groups of lipid molecules. The high affinity of the channels to lipid bilayers led to efficient mammalian cell membrane-insertion. The channels showed high effective activity against HepG2 cancer cells at concentration above 5.1 μM.

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Publication details

The article was received on 31 Jan 2018, accepted on 21 Mar 2018 and first published on 21 Mar 2018


Article type: Paper
DOI: 10.1039/C8FD00009C
Citation: Faraday Discuss., 2018, Accepted Manuscript
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    Synthetic channel that efficiently inserts into mammalian cell membranes and destroys cancer cells

    J. Chen, W. Haoyang, M. Zhang, G. Wu, Z. Li and J. Hou, Faraday Discuss., 2018, Accepted Manuscript , DOI: 10.1039/C8FD00009C

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