Jump to main content
Jump to site search


DNA decorated Cu9S5 nanoparticles as NIR light responsive drug carriers for tumor chemo-phototherapy

Abstract

Recently, near-infrared (NIR) light responsive drug delivery system has attracted much attention for tumor therapy. Herein, we have successfully constructed a smart nanocarrier system Cu9S5-PEI¬–DNA-DOX (labelled as CPD-DOX) based on the self-assembly of hydrophobic Cu9S5 nanoparticles (NPs), poly (ethylene imine) (PEI), double-stranded DNA (dsDNA) segments and anti-cancer drug doxorubicin (DOX). Among them, Cu9S5 nanoparticles (NPs) can serve as a nano-transducer for absorbing and converting near-infrared light to heat. Then, the hydrophobic layer of Cu9S5 NPs are coated by the dendritic polymer PEI through a simple approach. According to the temperature of tumor tissue and the photothermal effect of Cu9S5 NPs, we specially designed a DNA sequence with a suitable melting temperature for NIR-light-promoted denaturation of DNA helices and drug release when DOX intercalated into the dsDNA through noncovalent interaction. Notably, the DOX-loaded DNA can be decorated to the surface of Cu9S5 NPs by convenient electrostatic adsorption rather than chemical bonding. The experimental results show that dsDNA can maintain a stable helical structure under physiological conditions but unzip helix to release DOX upon NIR irradiation. Therefore, DOX can be safely delivered and released into cancer cells to exert anticancer effects. Based on in vitro cell cytotoxicity experiment, the CPD-DOX system had a synergistic effect for cancer cell apoptosis or death because of both the cytotoxicity of light-triggered DOX release and Cu9S5-NPs- mediated photothermal ablation effect. It is expected that the facile synthesis and low cost nanocarrier can improve the anticancer effect in contrast to the single chemotherapy or photothermal therapy mode.

Back to tab navigation

Publication details

The article was received on 27 Mar 2018, accepted on 28 Apr 2018 and first published on 30 Apr 2018


Article type: Paper
DOI: 10.1039/C8DT01174E
Citation: Dalton Trans., 2018, Accepted Manuscript
  •   Request permissions

    DNA decorated Cu9S5 nanoparticles as NIR light responsive drug carriers for tumor chemo-phototherapy

    S. Liang, Z. Xie, Y. Wei, Z. Cheng, Y. Han and J. Lin, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT01174E

Search articles by author

Spotlight

Advertisements