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Issue 28, 2018
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Bispidines for radiopharmaceuticals

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Abstract

Very rigid tetra-, penta-, hexa-, hepta- and octadentate bispidine ligands are well preorganized for specific coordination geometries. The broad range of coordination numbers, geometries and donor sets allows one to design and prepare bispidines for many specific metal ions and applications. Major requirements for radiopharmaceuticals are efficient labeling, inertness under physiological conditions and easy functionalization of the ligands with biological vectors. The reasons why bispidines are among the most favorable chelators for radiopharmaceutical applications, a comprehensive list of bispidine ligands and a range of examples where bispidines have been used to develop radiopharmaceuticals for future applications in diagnosis and therapy are discussed.

Graphical abstract: Bispidines for radiopharmaceuticals

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Publication details

The article was received on 22 Mar 2018, accepted on 16 May 2018 and first published on 17 May 2018


Article type: Perspective
DOI: 10.1039/C8DT01108G
Citation: Dalton Trans., 2018,47, 9202-9220
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    Bispidines for radiopharmaceuticals

    P. Comba, M. Kerscher, K. Rück and M. Starke, Dalton Trans., 2018, 47, 9202
    DOI: 10.1039/C8DT01108G

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