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Combined experimental and theoretical studies on selective sensing of zinc and pyrophosphate ions by rational designing of compartmental chemosensor probe: Dual sensing behaviour via secondary recognition approach and cell imaging studies

Abstract

A compartmental chemosensor probe HL has been designed and synthesized for the selective recognition of zinc ions over other transition metal ions via fluorescence “ON” strategy. The chemo-sensing behaviour of HL has been demonstrated through fluorescence, absorption and NMR spectroscopic techniques. The molecular structure of the zinc complex derived from HL was determined by X-ray crystallography. A probable mechanism of this selective sensing behavior was described on the basis of spectroscopic results and theoretical studies by density functional theory (DFT). The biological applicability of the chemosensor (HL) was examined via cell imaging on HeLa cells. This zinc complex served as secondary fluorescent probe responding for the pyrophosphate anion specifically over other anions. The fluorescence enhancement of HL in association with Zn2+ ions was quenched due to the presence of pyrophosphate (PPi). Thus a dual response has been established based on “OFF-ON-OFF” strategy for detection of both cation and anion. This phenomenon was utilized in the construction of “INHIBIT” logic gate.

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Publication details

The article was received on 16 Mar 2018, accepted on 28 Mar 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8DT01016A
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Combined experimental and theoretical studies on selective sensing of zinc and pyrophosphate ions by rational designing of compartmental chemosensor probe: Dual sensing behaviour via secondary recognition approach and cell imaging studies

    K. Ghosh, K. Mawai, S. nathani, P. Roy and U. P. singh, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT01016A

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