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Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

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Abstract

Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log kRS and the thiol dissociation constants pKRSH is disclosed: log kRS = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.

Graphical abstract: Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

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Publication details

The article was received on 06 Mar 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018


Article type: Communication
DOI: 10.1039/C8DT00852C
Citation: Dalton Trans., 2018, Advance Article
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    Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

    J. Dong, H. Tian, C. Song, T. Shi and L. I. Elding, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT00852C

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