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DNA interaction of non-chelating tinidazole-based coordination compounds. Structural, redox and cytotoxic properties

Abstract

Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair•••π interactions. The copper(II) compounds exhibits interesting redox properties originated from both the tnz and the metal ion. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(μ-Cl)Cl]2 7, which is further more efficient towards cancer cells, compared with normal cells.

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Publication details

The article was received on 22 Feb 2018, accepted on 09 May 2018 and first published on 09 May 2018


Article type: Paper
DOI: 10.1039/C8DT00716K
Citation: Dalton Trans., 2018, Accepted Manuscript
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    DNA interaction of non-chelating tinidazole-based coordination compounds. Structural, redox and cytotoxic properties

    N. Barba Behrens, R. Castro-Ramírez, N. Ortiz-Pastrana, A. B. Caballero, M. T. Zimmerman, B. S. Stadelman, A. A. E. Gaertner, J. L. Brumaghim, L. Korrodi-Gregório, R. Pérez Tomás and P. Gamez, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT00716K

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