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Issue 13, 2018
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Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

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Abstract

The reactions of [Pt3n(CO)6n]2− (n = 2–5) homoleptic Chini-type clusters with increasing amounts of 1,3,5-triaza-7-phosphaadamantane (PTA) result in the stepwise substitution of one terminal CO ligand per Pt3 triangular unit up to the formation of [Pt3n(CO)5n(PTA)n]2− (n = 2–5). Competition between the nonredox substitution with retention of the nuclearity and the redox fragmentation to afford lower nuclearity heteroleptic Chini-type clusters is observed as a function of the amount of PTA and the nuclearity of the starting cluster. Because of this, [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2− are more conveniently obtained via the oxidation of [Pt9(CO)15(PTA)3]2−. All the new species were spectroscopically characterized, and the structures of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2− were determined by single-crystal X-ray diffraction. These clusters may be viewed as heteroleptic Chini-type clusters composed of stacks of four and five Pt3(μ-CO)3(CO)2(PTA) units, respectively. The solubility in water of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2− has been determined and their cytotoxicity towards human ovarian (A2780) cancer cells and their cisplatin-resistant strain (A2780cisR) has been evaluated.

Graphical abstract: Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

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Publication details

The article was received on 18 Jan 2018, accepted on 15 Feb 2018 and first published on 16 Feb 2018


Article type: Paper
DOI: 10.1039/C8DT00228B
Citation: Dalton Trans., 2018,47, 4467-4477
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    Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

    L. K. Batchelor, B. Berti, C. Cesari, I. Ciabatti, P. J. Dyson, C. Femoni, M. C. Iapalucci, M. Mor, S. Ruggieri and S. Zacchini, Dalton Trans., 2018, 47, 4467
    DOI: 10.1039/C8DT00228B

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