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Microfluidic 68Ga-labeling: a proof of principle study

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Abstract

Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is a popular PET nuclide due to its favorable characteristics, like advantageous half-life (68 min) and independency of a cyclotron on-site for its production. Accordingly, several 68Ga-complexes for cancer imaging via PET have been made available during the last few years. In this work, 68Ga-labeled compounds were synthesized applying a commercially available microfluidic device for the first time. Therefore, a proof of principle study using three important radiotracers, [68Ga]Ga-PSMA-11, [68Ga]Ga-NODAGA-RGDyk and [68Ga]Ga-DOTA-NOC, was designed. For all three radioligands, various synthesis parameters were evaluated and the feasibility of using a continuous flow reactor was assessed. All of the precursors were successfully radiolabeled with a radiochemical yield higher than 80%, proving the principle that a microfluidic set-up is a suitable approach for the production of 68Ga-labeled tracers.

Graphical abstract: Microfluidic 68Ga-labeling: a proof of principle study

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Publication details

The article was received on 12 Jan 2018, accepted on 26 Mar 2018 and first published on 30 Mar 2018


Article type: Paper
DOI: 10.1039/C8DT00158H
Citation: Dalton Trans., 2018, Advance Article
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    Microfluidic 68Ga-labeling: a proof of principle study

    S. Pfaff, C. Philippe, V. Pichler, M. Hacker, M. Mitterhauser and W. Wadsak, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT00158H

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