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Issue 12, 2018
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Chirality in metal-based anticancer agents

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Abstract

Chiral natural biological molecules, such as nucleic acids and proteins, guide the research of chiral compounds. Chiral metal-based drugs are currently an interesting and rapidly growing field in anticancer research. This perspective focuses on chiral metal compounds with application in cancer chemotherapy. The different chiral metal-based anticancer agents and the extent to which the chiral resolution affects their biological properties are discussed. This perspective will aid the design of new potent and efficient chiral metal-based anticancer drugs that exploit their unique properties combined with their potential selectivity toward targeted chiral biomolecules.

Graphical abstract: Chirality in metal-based anticancer agents

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Publication details

The article was received on 09 Jan 2018, accepted on 07 Feb 2018 and first published on 08 Feb 2018


Article type: Perspective
DOI: 10.1039/C8DT00089A
Citation: Dalton Trans., 2018,47, 4017-4026
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    Chirality in metal-based anticancer agents

    Y. Wang, H. Huang, Q. Zhang and P. Zhang, Dalton Trans., 2018, 47, 4017
    DOI: 10.1039/C8DT00089A

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