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Fluorescent antitumor titanium(IV) salen complexes for cell imaging

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Abstract

Two differently substituted fluorescent salen Ti(IV) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

Graphical abstract: Fluorescent antitumor titanium(iv) salen complexes for cell imaging

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Publication details

The article was received on 21 Dec 2017, accepted on 24 Jan 2018 and first published on 24 Jan 2018


Article type: Communication
DOI: 10.1039/C7DT04828A
Citation: Dalton Trans., 2018, Advance Article
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    Fluorescent antitumor titanium(IV) salen complexes for cell imaging

    A. Tzubery, N. Melamed-Book and E. Y. Tshuva, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C7DT04828A

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