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Nickel(II) complexes of 3N ligand as a model for diketone cleaving unusual nickel(II)-dioxygenases enzymes

Abstract

The diketone substrate bound nickel(II) complexes of 2,6-bis(1-methylbenzimidazolyl)pyridine have been synthesized and characterized as relevant active site models for unusual diketone cleaving Ni(II)-dependent enzymes Ni-ARD and DKDO. The average Ni-Npy/benzim bond distances (2.050 - 2.107 Å) of model complexes are almost identical to the Ni-NHis bond distances of NiII-ARD (2.02 - 2.19 Å). The reaction of these adducts with dioxygen exhibited C-C cleavage with the rate of kO2, 5.24 - 73.71 × 10-3 M-1 s-1. The phenyl substituted adduct regioselectively elicits 52% of benzoic acid as the major product.

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Publication details

The article was received on 15 Dec 2017, accepted on 07 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C7DT04739H
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Nickel(II) complexes of 3N ligand as a model for diketone cleaving unusual nickel(II)-dioxygenases enzymes

    R. Ramasubramanian, K. Anandababu, M. Kumar and M. Ramasamy, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04739H

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