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Issue 12, 2018
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Nickel(II) complexes of a 3N ligand as a model for diketone cleaving unusual nickel(II)-dioxygenase enzymes

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Abstract

Diketone substrate bound nickel(II) complexes of 2,6-bis(1-methylbenzimidazolyl)pyridine have been synthesized and characterized as relevant active site models for unusual diketone cleaving Ni(II)-dependent enzymes Ni–ARD and DKDO. The average Ni–Npy/benzim bond distances (2.050–2.107 Å) of model complexes are almost identical to the Ni–NHis bond distances of NiII–ARD (2.02–2.19 Å). The reaction of these adducts with dioxygen exhibited C–C cleavage with the rate of kO2, 5.24–73.71 × 10−3 M−1 s−1. The phenyl substituted adduct regioselectively elicits 52% of benzoic acid as the major product.

Graphical abstract: Nickel(ii) complexes of a 3N ligand as a model for diketone cleaving unusual nickel(ii)-dioxygenase enzymes

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Publication details

The article was received on 15 Dec 2017, accepted on 07 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C7DT04739H
Citation: Dalton Trans., 2018,47, 4049-4053
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    Nickel(II) complexes of a 3N ligand as a model for diketone cleaving unusual nickel(II)-dioxygenase enzymes

    R. Ramasubramanian, K. Anandababu, M. Kumar and R. Mayilmurugan, Dalton Trans., 2018, 47, 4049
    DOI: 10.1039/C7DT04739H

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