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Synthesis and application of a water-soluble phosphorescent iridium complex as turn-on sensing material for human serum albumin

Abstract

A novel water-soluble cyclometallated iridium complex [Ir(pq-COOH)2FDS]- (pq-COOH = 2-phenylquinoline-4-carboxylic acid, FDS=3-(2-Pyridyl)-5,6-bis(4-sulfophenyl)-1,2,4-triazine dianions) (abbreviated as Ir) was synthesized and its phosphorescent property was comprehensively studied. It was found that the complex exhibited strong phosphorescence peaked at 634 nm in neutral condition (maximized at pH 8.0). Its phosphorescence decreases with the increase of acidity in aqueous solution. At pH 2.0 the quenched phosphorescence can be resumed upon the addition of human serum albumin (HSA) due to the hydrophobic and electrostatic interactions between HSA and Ir. Based on this phenomenon, a “turn on” type phosphorescence probe was developed for the detection of HSA. Under the optimal conditions, a wide calibration range of 1-280 nM was obtained with a limit of detection of 0.8 nM for HSA. The phosphorescence probe was successfully applied to the determination of HSA in blood serum and urine samples.

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Publication details

The article was received on 11 Dec 2017, accepted on 09 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7DT04676F
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Synthesis and application of a water-soluble phosphorescent iridium complex as turn-on sensing material for human serum albumin

    C. Huang, G. Ran, Y. Zhao, C. Wang and Q. Song, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04676F

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