Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds

Author affiliations

Abstract

The [Cu(L)Cl2]2 and [Pt(L)Cl2] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl2 and cis-[PtCl2(DMSO)2]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and PC3 cells showed that [Cu(L)Cl2]2 is an efficient cytotoxic agent whereas [Pt(L)Cl2] is not toxic, illustrating the crucial role played by the nature of the metal ion in the corresponding biological activity.

Graphical abstract: Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Dec 2017, accepted on 08 Mar 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C7DT04604A
Citation: Dalton Trans., 2018,47, 4902-4908
  •   Request permissions

    Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds

    J. Grau, C. Renau, A. B. Caballero, A. Caubet, M. Pockaj, J. Lorenzo and P. Gamez, Dalton Trans., 2018, 47, 4902
    DOI: 10.1039/C7DT04604A

Search articles by author

Spotlight

Advertisements