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A ferrocene∩europium assembly showing phototriggered anticancer activity and fluorescent modality imaging

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Abstract

Two macrocyclic ferrocenophanes containing a coumarin fluorophore, Se2N[7]ferrocenophane (fc1), and Se4N2[7,7]ferrocenophane (fc2), construct an assembly of fc1-H+⋯ClO4⋯[Eu(C10H21COO)2(H2O)2(ClO4)] (fc1∩Eu) and fc2-2H+⋯{ClO4⋯[Eu(C10H21COO)2(H2O)2(ClO4)]}2 (fc2∩Eu) via a N–H⋯O hydrogen bond and a coordinate bond between EuIII and ClO4. In fc1∩Eu, UV light irradiation triggers non-covalent bond cleavage to release a ferrocenium and EuII complex, accompanying chromism and luminescence signals. Investigations through the steady-state UV-vis absorption, fluorescence, time-resolved fluorescence, femtosecond transient absorption spectra and electrochemical characterization elucidate a stepwise mechanism: firstly, an effective electron transfer occurs from a ferrocene unit to the singlet state of a coumarin unit; the following proton-coupled electron transfer (PCET) reduces EuIII and results in a non-covalent interaction cleavage. Further in vitro exploration of fc1∩Eu in HepG2 cells demonstrated phototriggered integrated cell cytotoxicity and fluorescent modality imaging.

Graphical abstract: A ferrocene∩europium assembly showing phototriggered anticancer activity and fluorescent modality imaging

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Publication details

The article was received on 29 Nov 2017, accepted on 18 Dec 2017 and first published on 19 Dec 2017


Article type: Paper
DOI: 10.1039/C7DT04492E
Citation: Dalton Trans., 2018, Advance Article
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    A ferrocene∩europium assembly showing phototriggered anticancer activity and fluorescent modality imaging

    J. Qu, Q. Xia, W. Ji, S. Jing, D. Zhu, L. Li, L. Huang, Z. An, C. Xin, Y. Ni, M. Li, J. Jia, Y. Song and W. Huang, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C7DT04492E

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