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Evaluation of a Novel Platinum(II)Based AIE Compound-Encapsulated MesoporousSilica Nanoparticles for Cancer Theranostic Application

Abstract

Advanced biomedical research has established that cancer is a multifactorial disorder which is highly heterogeneous in nature and responds differently to different treatment modalities, due to which constant monitoring of the therapy response is becoming extremely important. To accomplish this, different theranostic formulations have been evaluated.However, most of them were found to suffer from several limitations extending from poor resolution, radiation damage, to high costs. In order to develop a better theranostic modality, we have designed and synthesized a novel platinum(II)-based ‘aggregation induced emission’ (AIE) molecule (named BMPP-Pt) which showed strong intra-cellular fluorescence and also simultaneously exhibited potent cytotoxic activity. Due to this dual functionality, we wanted to explore the possibility of using this compound as a single molecule based theranostic modality. The compound was characterized using elemental analysis, NMR and IR spectroscopy, mass spectrometry and single crystal X-ray structure determination. BMPP-Ptwas found to exhibit a high AIE property with emission maxima at 497 nm. For more efficient cancer cell targeting, BMPP-Pt was encapsulated into mesoporous silica nanoparticles (Pt-MSNPs) and the MSNPs were further surface modified with anti-EpCAM aptamer(Pt-MSNP-E). Pt-MSNP exhibited higher intracellular fluorescence compared to free BMPP-Pt, though both of them induced a similar degree of cell death via apoptosis pathway, possibly via cell cycle arrest at the G1 phase. Anti-EpCAM aptamer modification was found to increase both cytotoxicity and intracellular fluorescence compared to the unmodified MSNPs. Our study showed that the EpCAM functionalized BMPP-Pt loaded MSNPs can efficiently internalize and induce apoptosis of cancer cells as well as to show strong intracellular fluorescence. This study provides clues towards the development of a potential single compound based theranostic modality in future.

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Supplementary files

Publication details

The article was received on 09 Nov 2017, accepted on 14 Feb 2018 and first published on 15 Feb 2018


Article type: Paper
DOI: 10.1039/C7DT04232A
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Evaluation of a Novel Platinum(II)Based AIE Compound-Encapsulated MesoporousSilica Nanoparticles for Cancer Theranostic Application

    S. pasha, L. Fageria, I. R. Laskar, R. chowghury, A. Roy, N. P. Rath, C. Climent and P. Alemany, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04232A

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