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Issue 11, 2018
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Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)2dppz]2+ in live cells using cucurbit[7]uril as a delivery system

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Abstract

Here, we report the delivery of a cell-impermeable [Ru(bpy)2dppz]2+ complex across a cell membrane using a cucurbit[7]uril molecular container. Encapsulation of complex 1 in the cucurbit[7]uril cavity showed an 830-fold enhancement in the luminescence intensity of the non-emissive complex in aqueous solution. This molecular light-switch effect stems from the incorporation of the dppz ligand of 1 inside the CB7 cavity and can be attributed to long range coulombic forces between Ru2+ and the carbonyl portal of CB7 via CH⋯O interactions. This is reflected in the 1H-NMR experiments, and further corroborated by theoretical calculations.

Graphical abstract: Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)2dppz]2+ in live cells using cucurbit[7]uril as a delivery system

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Publication details

The article was received on 09 Nov 2017, accepted on 05 Feb 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7DT04230B
Citation: Dalton Trans., 2018,47, 3857-3863
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    Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)2dppz]2+ in live cells using cucurbit[7]uril as a delivery system

    M. N. Shinde, S. S. Rao, S. P. Gejji and A. A. Kumbhar, Dalton Trans., 2018, 47, 3857
    DOI: 10.1039/C7DT04230B

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