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Issue 14, 2018
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Anti-tumour active gold(I), palladium(II) and ruthenium(II) complexes with thio- and selenoureato ligands: a comparative study

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Abstract

We report the results of a comparative study of the biological activity of a series of gold(I), palladium(II) and ruthenium(II) complexes containing deprotonated thio- and selenoureato ligands. A library of compounds was prepared and characterised by spectroscopic methods and the solid-state structures of several derivatives were determined by single crystal X-ray diffraction. The in vitro activity of these compounds was evaluated in mammary and ovarian carcinoma, acute lymphatic and acute and chronic myeloid leukemia cell lines. At lower concentrations Ru- and Pd-containing compounds displayed stronger anti-cancer effects than the gold compounds. In all cases, the selenium derivatives proved to be more active than the corresponding sulfur compounds.

Graphical abstract: Anti-tumour active gold(i), palladium(ii) and ruthenium(ii) complexes with thio- and selenoureato ligands: a comparative study

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Publication details

The article was received on 06 Nov 2017, accepted on 10 Mar 2018 and first published on 12 Mar 2018


Article type: Paper
DOI: 10.1039/C7DT04180B
Citation: Dalton Trans., 2018,47, 5055-5064
  • Open access: Creative Commons BY license
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    Anti-tumour active gold(I), palladium(II) and ruthenium(II) complexes with thio- and selenoureato ligands: a comparative study

    A. Molter, S. Kathrein, B. Kircher and F. Mohr, Dalton Trans., 2018, 47, 5055
    DOI: 10.1039/C7DT04180B

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