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Nano-graphene oxide-UCNP-Ce6 covalently constructed nanocomposites for NIR-mediated bioimaging and PTT/PDT combinatorial therapy

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Abstract

NIR light-induced imaging-guided cancer therapy is an encouraging route in the cancer theranostic field. Herein, we describe a novel nanoscale proposal, which is established by covalently implanting core–shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) by a process utilizing polyethylene glycol (PEG), and consequently loading Chlorin e6 (Ce6) onto the surface of NGO. The acquired NGO-UCNP-Ce6 (NUC) nanocomposites can not only be employed as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate reactive oxygen species (ROS) under 808 nm light excitation for photodynamic therapy (PDT); over and above, they can swiftly and proficiently translate the 808 nm photon into thermal energy for photothermal therapy (PTT). An extraordinarily enhanced and synchronized therapeutic effect paralleled to the individual PTT or PDT is achieved, rendering extraordinary therapeutic effectiveness for cancer treatment. Consequently, profiting from this inimitable multifunctional nanohybrid, the NUCs synthesized here are encouraging as a cohesive theranostic probe for impending UCL imaging-guided combinatorial PDT/PTT.

Graphical abstract: Nano-graphene oxide-UCNP-Ce6 covalently constructed nanocomposites for NIR-mediated bioimaging and PTT/PDT combinatorial therapy

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Publication details

The article was received on 02 Nov 2017, accepted on 02 Feb 2018 and first published on 02 Feb 2018


Article type: Paper
DOI: 10.1039/C7DT04141A
Citation: Dalton Trans., 2018, Advance Article
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    Nano-graphene oxide-UCNP-Ce6 covalently constructed nanocomposites for NIR-mediated bioimaging and PTT/PDT combinatorial therapy

    A. Gulzar, J. Xu, D. Yang, L. Xu, F. He, S. Gai and P. Yang, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C7DT04141A

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