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Synthesis, Functionalization, and Applications of Metal-Organic Frameworks in Biomedicine

Abstract

Metal-organic frameworks (MOFs), also known as coordination polymers, attract extensive researchers due to their unique physical structure and potentially vast applications in the past few decades. In this review, we outline the recent progress in synthesis, functionalization, and applications of MOFs in biomedicine, mainly focus on two promising yet challenging area, i.e. drug delivery and biosensing applications. A major challenge is proper functionalization of MOFs with demanding properties suitable for biomedical applications. Extensive studies on MOFs in biomedicine have led to substantial progress in the control of key properties of MOFs such as toxicity, size and shape, and biological stability. Due to their flexible composition, pore size and easy functionalization properties, MOFs can be utilized as key components for the development of various functional systems, and their applications in drug delivery and biosensing will be reviewed. Finally, future trends and perspectives in these research areas will be also outlined.

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Publication details

The article was received on 01 Nov 2017, accepted on 08 Jan 2018 and first published on 08 Jan 2018


Article type: Perspective
DOI: 10.1039/C7DT04116K
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Synthesis, Functionalization, and Applications of Metal-Organic Frameworks in Biomedicine

    W. Chen and C. Wu, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04116K

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