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Redox responsive UCNPs-DPA conjugated NGO-PEG-BPEI for cancer theranostic

Abstract

The disulfide bond (−S−S−) is an enormously cherished functional group in a variety of chemical and biological agents that parade effective reactivity or biological activities (e.g., antitumor activities). Disulfide bonds prevailing in proteins are somewhat oxidative in the extracellular space; yet, such disulfide bonds can be rarely found inside cells because of the disulfide cleavage reactions facilitated by the plenty of cellular free thiols, including glutathione (GSH), which is the utmost copious thiol-containing small molecule. Interestingly intracellular GSH concentration is considerably advanced in cancer cells than that in the analogous normal cells; this feature may ascertain to be significant in the development of anticancer drug delivery systems (DDS).Moreover upconversion nanoparticles (UCNPs) have been extensively scrutinized in multimodal imaging, photodynamic therapy (PDT) and photothermal therapy. UCNPs exploit near-infrared excitation instead of ultraviolet excitation, and possess exclusive properties counting as high intensified elevated penetration depth in biological samples, diminishing background autofluorescence, photobleaching and photo damaging of the biological specimens. These enthralling optical topographies of UCNPs, may perhaps enrich their prospects in the arenas of imaging and therapy. Graphene has materialized as a flat monolayer of carbon atoms that are firmly crammed into a two-dimensional (2D) honeycomb lattice. There have been widespread research going on graphene in recent years due to its exclusive shape/size as well as innumerable fascinating physical and chemical properties Owing to the high optical absorption in the near-infrared (NIR) region, graphene and GO have been extensively applied for photothermal therapy (PTT). Herein this paper we try to pool the properties of these compounds into a single platform by conjugating UCNPs and NGO-PEG-BPEI-DOX into a single platform for chemotherapy and photothermal therapy.

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Publication details

The article was received on 31 Oct 2017, accepted on 22 Jan 2018 and first published on 22 Jan 2018


Article type: Paper
DOI: 10.1039/C7DT04093H
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Redox responsive UCNPs-DPA conjugated NGO-PEG-BPEI for cancer theranostic

    A. Gulzar, J. Xu, L. Xu, P. Yang, F. He, D. Yang, G. An and M. B. B. Ansari, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04093H

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