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The Synthesis of LA-Fe3O4@PDA-PEG-DOX for Photothermal-Chemotherapy Therapy

Abstract

A facile methodology is presented to construct a multifunctional nanocomposite, which integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, the magnetic Fe3O4@polydopamine core-shell nanoparticles (Fe3O4@PDA) were synthesized via reversed-phase microemulsion approach. By varying the amount of DA, Fe3O4@PDA with particle size of 28-38 nm can be obtained. To further make sure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were modified on to Fe3O4@PDA (LA-Fe3O4@PDA-PEG), whose fast photothermal conversion is derived the combination of Fe3O4 and PDA with high near infrared (NIR) absorption. And then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded on to LA-Fe3O4@PDA-PEG via electrostatic and π–π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was owing to the nanoparticle size and abundant asialoglycoprotein receptor on HepG2 cells. Besides, the external magnetic field also can improve the uptake, especially, when the magnet was placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, LA-Fe3O4@PDA-PEG-DOX nanocomposite showed the potential application on hepatocyte therapy.

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Publication details

The article was received on 30 Oct 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Paper
DOI: 10.1039/C7DT04080F
Citation: Dalton Trans., 2018, Accepted Manuscript
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    The Synthesis of LA-Fe3O4@PDA-PEG-DOX for Photothermal-Chemotherapy Therapy

    Y. H. Chen, H. Lin, F. Zhang, Q. Wang, R. Tong, N. An and F. Qu, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C7DT04080F

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