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Issue 18, 2018
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A novel metallogel based approach to synthesize (Mn, Cu) doped ZnS quantum dots and labeling of MCF-7 cancer cells

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Abstract

The present study aims to formulate a common synthetic strategy for preparing quantum dots (QDs) in a greener way by using combination of popular methods, viz. a colloidal method with suitable capping agent and low molecular weight gel based synthesis. Pyridine dicarboxylic acid (PDC) in presence of AlCl3 forms a stable metallogel, which serves as an excellent medium for selective ZnS QD synthesis. The aromatic pyridine moiety, well known for being a capping agent, indeed plays its part in the run up to QD synthesis. To the best of our knowledge, this is the first example of a metallogel based doped ZnS QD synthesis. Altering the doping material and its composition changes the properties of the QDs, but herein we also tried to establish how these changes affect the gel morphology and stability of both gel and QDs. We further demonstrate, by using live cell confocal microscopy, the delivery of QDs Cu ZnS and MnZnS nanomaterials in the nucleus and the cytoplasm of human breast cancer cells (MCF7), implicating the use of metallogel based QDs for bio-imaging and bio-labeling.

Graphical abstract: A novel metallogel based approach to synthesize (Mn, Cu) doped ZnS quantum dots and labeling of MCF-7 cancer cells

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Publication details

The article was received on 13 Oct 2017, accepted on 12 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C7DT03864J
Citation: Dalton Trans., 2018,47, 6557-6569
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    A novel metallogel based approach to synthesize (Mn, Cu) doped ZnS quantum dots and labeling of MCF-7 cancer cells

    S. Bhowal, A. Ghosh, S. P. Chowdhuri, R. Mondal and B. B. Das, Dalton Trans., 2018, 47, 6557
    DOI: 10.1039/C7DT03864J

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