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Issue 3, 2018
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Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents

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Abstract

We present a novel design to use metal–organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(IV) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host–guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.

Graphical abstract: Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents

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Publication details

The article was received on 20 Sep 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7DT03537C
Citation: Dalton Trans., 2018,47, 670-674
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    Nanoparticles of metal–organic cages designed to encapsulate platinum-based anticancer agents

    Z. Yue, H. Wang, D. J. Bowers, M. Gao, M. Stilgenbauer, F. Nielsen, J. T. Shelley and Y. Zheng, Dalton Trans., 2018, 47, 670
    DOI: 10.1039/C7DT03537C

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