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Mechanism and reactivity of catalytic propargylic substitution reactions via metal–allenylidene intermediates: a theoretical perspective

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Abstract

Development of transition metal-catalyzed propargylic substitution reactions is still in progress as a novel synthetic tool, while a variety of allylic substitution reactions have been well established and widely used in organic synthesis. In this review, we summarize the mechanism and reactivity of transition metal-catalyzed propargylic substitution reactions from a theoretical point of view. We classify the reaction mechanisms for transition metal-catalyzed propargylic substitution reactions which have been reported to date, and then discuss, in particular, the reactions via metal–allenylidene intermediates.

Graphical abstract: Mechanism and reactivity of catalytic propargylic substitution reactions via metal–allenylidene intermediates: a theoretical perspective

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Publication details

The article was received on 10 Jul 2017, accepted on 16 Oct 2017 and first published on 17 Oct 2017


Article type: Minireview
DOI: 10.1039/C7CY01382E
Citation: Catal. Sci. Technol., 2018, Advance Article
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    Mechanism and reactivity of catalytic propargylic substitution reactions via metal–allenylidene intermediates: a theoretical perspective

    K. Sakata and Y. Nishibayashi, Catal. Sci. Technol., 2018, Advance Article , DOI: 10.1039/C7CY01382E

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