Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Author affiliations

Abstract

The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that range from direct assembly, encapsulation and composite formation. We will discuss factors that affect the efficacy of nanoassemblies for delivery from the perspective of both nanoparticles and proteins. Challenges in the field, particularly achieving effective cytosolar protein delivery through endosomal escape or evasion are discussed.

Graphical abstract: Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Back to tab navigation

Publication details

The article was received on 03 Jan 2018 and first published on 14 Mar 2018


Article type: Tutorial Review
DOI: 10.1039/C8CS00008E
Citation: Chem. Soc. Rev., 2018,47, 3421-3432
  •   Request permissions

    Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

    F. Scaletti, J. Hardie, Y. Lee, D. C. Luther, M. Ray and V. M. Rotello, Chem. Soc. Rev., 2018, 47, 3421
    DOI: 10.1039/C8CS00008E

Search articles by author

Spotlight

Advertisements