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Protein cage assembly across multiple length scales

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Within the materials science community, proteins with cage-like architectures are being developed as versatile nanoscale platforms for use in protein nanotechnology. Much effort has been focused on the functionalization of protein cages with biological and non-biological moieties to bring about new properties of not only individual protein cages, but collective bulk-scale assemblies of protein cages. In this review, we report on the current understanding of protein cage assembly, both of the cages themselves from individual subunits, and the assembly of the individual protein cages into higher order structures. We start by discussing the key properties of natural protein cages (for example: size, shape and structure) followed by a review of some of the mechanisms of protein cage assembly and the factors that influence it. We then explore the current approaches for functionalizing protein cages, on the interior or exterior surfaces of the capsids. Lastly, we explore the emerging area of higher order assemblies created from individual protein cages and their potential for new and exciting collective properties.

Graphical abstract: Protein cage assembly across multiple length scales

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Publication details

The article was received on 29 Nov 2017 and first published on 02 Mar 2018

Article type: Review Article
DOI: 10.1039/C7CS00818J
Citation: Chem. Soc. Rev., 2018, Advance Article
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    Protein cage assembly across multiple length scales

    W. M. Aumiller, M. Uchida and T. Douglas, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C7CS00818J

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