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A guide to integrating immunohistochemistry and chemical imaging

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Abstract

Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.

Graphical abstract: A guide to integrating immunohistochemistry and chemical imaging

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Publication details

The article was received on 24 Jan 2018 and first published on 15 Mar 2018


Article type: Tutorial Review
DOI: 10.1039/C7CS00610A
Citation: Chem. Soc. Rev., 2018, Advance Article
  • Open access: Creative Commons BY license
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    A guide to integrating immunohistochemistry and chemical imaging

    D. P. Bishop, N. Cole, T. Zhang, P. A. Doble and D. J. Hare, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C7CS00610A

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