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Issue 4, 2018
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Release of small bioactive molecules from physical gels

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Abstract

Pharmaceutical drugs with low water solubility have always received great attention within the scientific community. The reduced bioavailability and the need of frequent administrations have motivated the investigation of new drug delivery systems. Within this context, drug carriers that release their payload in a sustained way and hence reduce the administration rate are highly demanded. One interesting strategy to meet these requirements is the entrapment of the drugs into gels. So far, the most investigated materials for such drug-loaded gels are derived from polymers and based on covalent linkages. However, over the last decade the use of physical (or supramolecular) gels derived from low molecular weight compounds has experienced strong growth in this field, mainly due to important properties such as injectability, stimuli responsiveness and ease of synthesis. This review summarizes the use of supramolecular gels for the encapsulation and controlled release of small therapeutic molecules.

Graphical abstract: Release of small bioactive molecules from physical gels

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Publication details

The article was received on 08 Sep 2017 and first published on 22 Jan 2018


Article type: Review Article
DOI: 10.1039/C7CS00515F
Citation: Chem. Soc. Rev., 2018,47, 1484-1515
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    Release of small bioactive molecules from physical gels

    J. Mayr, C. Saldías and D. Díaz Díaz, Chem. Soc. Rev., 2018, 47, 1484
    DOI: 10.1039/C7CS00515F

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