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A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

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Abstract

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.

Graphical abstract: A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

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Publication details

The article was received on 26 May 2017 and first published on 26 Jan 2018


Article type: Tutorial Review
DOI: 10.1039/C7CS00386B
Citation: Chem. Soc. Rev., 2018, Advance Article
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    A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

    K. J. R. Murauski, A. A. Jaworski and K. A. Scheidt, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C7CS00386B

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