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Calcium-based biomaterials for diagnosis, treatment, and theranostics

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Abstract

Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates, calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing to their excellent biocompatibility and biodegradability. In recent years, CaXs biomaterials have been strategically integrated with imaging contrast agents and therapeutic agents for various molecular imaging modalities including fluorescence imaging, magnetic resonance imaging, ultrasound imaging or multimodal imaging, as well as for various therapeutic approaches including chemotherapy, gene therapy, hyperthermia therapy, photodynamic therapy, radiation therapy, or combination therapy, even imaging-guided therapy. Compared with other inorganic biomaterials such as silica-, carbon-, and gold-based biomaterials, CaXs biomaterials can dissolve into nontoxic ions and participate in the normal metabolism of organisms. Thus, they offer safer clinical solutions for disease theranostics. This review focuses on the state-of-the-art progress in CaXs biomaterials, which covers from their categories, characteristics and preparation methods to their bioapplications including diagnosis, treatment, and theranostics. Moreover, the current trends and key problems as well as the future prospects and challenges of CaXs biomaterials are also discussed at the end.

Graphical abstract: Calcium-based biomaterials for diagnosis, treatment, and theranostics

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Publication details

The article was received on 16 Oct 2016 and first published on 20 Dec 2017


Article type: Review Article
DOI: 10.1039/C6CS00746E
Citation: Chem. Soc. Rev., 2018, Advance Article
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    Calcium-based biomaterials for diagnosis, treatment, and theranostics

    C. Qi, J. Lin, L. Fu and P. Huang, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C6CS00746E

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