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Chiral phosphoric acid catalysis: from numbers to insights

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Abstract

Chiral phosphoric acids (CPAs) have emerged as powerful organocatalysts for asymmetric reactions, and applications of computational quantum chemistry have revealed important insights into the activity and selectivity of these catalysts. In this tutorial review, we provide an overview of computational tools at the disposal of computational organic chemists and demonstrate their application to a wide array of CPA catalysed reactions. Predictive models of the stereochemical outcome of these reactions are discussed along with specific examples of representative reactions and an outlook on remaining challenges in this area.

Graphical abstract: Chiral phosphoric acid catalysis: from numbers to insights

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Publication details

The article was received on 20 Nov 2017 and first published on 22 Jan 2018


Article type: Tutorial Review
DOI: 10.1039/C6CS00475J
Citation: Chem. Soc. Rev., 2018, Advance Article
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    Chiral phosphoric acid catalysis: from numbers to insights

    R. Maji, S. C. Mallojjala and S. E. Wheeler, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C6CS00475J

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