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Microsolvated complexes of ibuprofen as revealed by high-resolution rotational spectroscopy

Abstract

Hydrogen-bonded complexes between ibuprofen and water generated in a supersonic expansion were characterized by chirped-pulse Fourier transform microwave spectroscopy in the 2-8 GHz frequency range. Four spectra were observed allowing to determine their rotational parameters. Comparison with quantum-chemical calculations led to their identification as the lowest energy 1:1 ibuprofen – water complexes. These correspond to the complexes between water and the four different conformers of ibuprofen previously detected in the gas phase, owing to their similar stabilization energies and abundances. Water seems to not change the conformational distribution of ibuprofen.

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Publication details

The article was received on 15 Feb 2018, accepted on 25 Apr 2018 and first published on 03 May 2018


Article type: Paper
DOI: 10.1039/C8CP01088A
Citation: Phys. Chem. Chem. Phys., 2018, Accepted Manuscript
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    Microsolvated complexes of ibuprofen as revealed by high-resolution rotational spectroscopy

    P. Pinacho, A. Krin, C. Pérez, S. Zinn, J. C. C. López, S. Blanco and M. Schnell, Phys. Chem. Chem. Phys., 2018, Accepted Manuscript , DOI: 10.1039/C8CP01088A

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