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Issue 15, 2018
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Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

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Abstract

We demonstrate that 1H–13C solid-state MAS NMR is suitable to detect liquid disordered/liquid ordered phase coexistence in a DOPC/DPPC/cholesterol mixture with natural abundance of isotopes as an alternative to 2H NMR. Such methodology is potentially applicable to study lipid phase coexistence phenomena in biological matter with high lipid content, e.g. lung surfactant or myelin, for which isotopic labeling is not possible.

Graphical abstract: Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

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Publication details

The article was received on 12 Feb 2018, accepted on 13 Mar 2018 and first published on 13 Mar 2018


Article type: Communication
DOI: 10.1039/C8CP01012A
Citation: Phys. Chem. Chem. Phys., 2018,20, 9751-9754
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    Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

    L. Löser, K. Saalwächter and T. Mendes Ferreira, Phys. Chem. Chem. Phys., 2018, 20, 9751
    DOI: 10.1039/C8CP01012A

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