Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Discrimination and quantification of sulfathiazole polytypes using low-frequency Raman spectroscopy

Author affiliations

Abstract

Sulfathiazole forms II, III and IV are polytypes where common monolayers accumulate in different stacking modes. These polytypes are difficult to identify using conventional analytical techniques when they concomitantly crystallize. However, the use of low-frequency Raman spectroscopy enables discrimination of these polytypes and can determine the ratio of forms III and IV, which are the most challenging pair for quantification. A Hydrogen/deuterium exchange study suggests that characteristic patterns below 100 cm−1 predominantly come from differences of superstructure geometries, especially layer stacking, rather than hydrogen-bond geometries. This study demonstrates that low-frequency Raman spectroscopy has advantages for both polytypic discrimination and quantification.

Graphical abstract: Discrimination and quantification of sulfathiazole polytypes using low-frequency Raman spectroscopy

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Jan 2018, accepted on 23 Feb 2018 and first published on 23 Feb 2018


Article type: Paper
DOI: 10.1039/C8CE00081F
Citation: CrystEngComm, 2018,20, 1928-1934
  •   Request permissions

    Discrimination and quantification of sulfathiazole polytypes using low-frequency Raman spectroscopy

    K. Iwata, M. Karashima, Y. Ikeda, M. Inoue and T. Fukami, CrystEngComm, 2018, 20, 1928
    DOI: 10.1039/C8CE00081F

Search articles by author

Spotlight

Advertisements