Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

Engineering oxygen vacancies through construction of morphology maps for bio-responsive nanoceria for osteosarcoma therapy

Author affiliations

Abstract

The present work provides guidelines for the engineering of oxygen vacancy concentrations using morphology-maps based on the characteristics of nanoceria (CeO2−x) nanocubes, nanorods, and truncated nanooctahedra. These were characterised by XRD, TEM, BET, DLS, and XPS. The morphology maps reveal that the redox performance, particle size, and surface roughness (apparent porosity) can be optimised by engineering the oxygen vacancy concentrations, but the morphology is dominated by the reaction temperature. However, the oxygen vacancy concentration is controlled by the concentration of the NaOH precipitant/oxidant. These vacancies can be potentially located at the surface, subsurface, and bulk regions, but the subsurface vacancies provide the principal redox activity. The biological effects of nanoceria in terms of oxygen vacancies were analysed in normal and cancer cells. Nanoceria particles exhibit antioxidant and cytoprotective effects at physiological pH 7.4 but prooxidant and cytotoxic effects at tumour microenvironment pH 6.4. The relative redox performances and cytotoxicities are in the order nanocubes < nanorods < truncated nanooctahedra, which is a direct reflection of the relative oxygen vacancy concentrations. The redox performance of nanoceria has been contextualised by cellular uptake and its quantification in osteosarcoma cells.

Graphical abstract: Engineering oxygen vacancies through construction of morphology maps for bio-responsive nanoceria for osteosarcoma therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Jan 2018, accepted on 10 Feb 2018 and first published on 12 Feb 2018


Article type: Paper
DOI: 10.1039/C8CE00001H
Citation: CrystEngComm, 2018,20, 1536-1545
  •   Request permissions

    Engineering oxygen vacancies through construction of morphology maps for bio-responsive nanoceria for osteosarcoma therapy

    R. Mehmood, X. Wang, P. Koshy, J. L. Yang and C. C. Sorrell, CrystEngComm, 2018, 20, 1536
    DOI: 10.1039/C8CE00001H

Search articles by author

Spotlight

Advertisements