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Issue 7, 2018
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Co-crystals and salts of vanillic acid and vanillin with amines

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Abstract

Vanillin (VAN) and its oxidized form vanillic acid (VA) have successfully formed a series of co-crystals and salts. VAN formed a co-crystal with isonicotinamide (INM) and a co-crystal hydrate with theobromine (THB). Binary co-crystals of VA with isonicotinamide (INM), hexamethylenetetramine (HEXA), phenazine (PHZ) and pyrazine-N-oxide (PZO) were obtained. Interestingly, a ternary co-crystal resulted from a 1 : 1 : 1 ratio of VA, caffeine (CAF) and nicotinamide (NAM). Salt hydrates were also formed between piperazine (PPZ) and 1,4-diazabicyclo[2.2.2]octane (DABCO) with VA. All co-crystals and salts were characterized by X-ray diffraction techniques, thermal analysis and infrared spectroscopy.

Graphical abstract: Co-crystals and salts of vanillic acid and vanillin with amines

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Publication details

The article was received on 22 Nov 2017, accepted on 05 Jan 2018 and first published on 08 Jan 2018


Article type: Paper
DOI: 10.1039/C7CE02022H
Citation: CrystEngComm, 2018,20, 896-905
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    Co-crystals and salts of vanillic acid and vanillin with amines

    F. M. Amombo Noa and G. Mehlana, CrystEngComm, 2018, 20, 896
    DOI: 10.1039/C7CE02022H

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