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Effects of inorganic additives on polymorphs of glycine in microdroplets

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Abstract

Salt-dependent polymorphic control of glycine was investigated by using the microdroplet technique in this work. Sodium chloride (NaCl) was chosen as the additive to probe the influence of inorganic ions on the polymorphic nucleation of glycine. The thermodynamics and nucleation kinetics of glycine polymorphs in microdroplets were systematically analyzed based on the microdroplet technique. The crystal structures of the polymorphs were confirmed by powder X-ray diffraction (PXRD). The results illustrate that the critical concentration of NaCl required to induce the pure γ-form in the microdroplets is lower than that in the conventional method, which means that the microdroplet technique is more sensitive for the control of polymorph nucleation. The polymorphic nucleation selectivity of glycine was then discussed in view of classical nucleation theory. The results demonstrate that NaCl reduces the nucleation energy barrier of the γ-form of glycine, and for the same form of glycine, crystallization by the conventional method has a higher interfacial tension than in microdroplets.

Graphical abstract: Effects of inorganic additives on polymorphs of glycine in microdroplets

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Publication details

The article was received on 08 Nov 2017, accepted on 21 Nov 2017 and first published on 21 Nov 2017


Article type: Paper
DOI: 10.1039/C7CE01942D
Citation: CrystEngComm, 2018, Advance Article
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    Effects of inorganic additives on polymorphs of glycine in microdroplets

    L. Ding, S. Zong, L. Dang, Z. Wang and H. Wei, CrystEngComm, 2018, Advance Article , DOI: 10.1039/C7CE01942D

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