Jump to main content
Jump to site search

Issue 3, 2018
Previous Article Next Article

Pyrene-box capsules for adaptive encapsulation and structure determination of unstable or non-crystalline guest molecules

Author affiliations

Abstract

“Pyrene-box” cages easily crystallize from aqueous solutions and readily encapsulate compounds of biological interest. These host–guest systems can be obtained under ambient conditions from 1,3,5,8-pyrenetetrasulfonate (PTS), guanidinium derivatives (G+) and biogenic guests bearing cationic groups. Out of the many examples of synthetic molecular capsules, Pyrene box cages are completely responding to the requirements of green chemistry: non-toxic, water soluble, cheap, commercially available compounds. The “Pyrene-Box” cages have been used for the in situ encapsulation of unstable or non-crystalline biogenic compounds, allowing the complete molecular structure determination of species that do not crystallize by themselves. The encapsulated guests have a reduced motional degrees of freedom which is obtained via their anchoring to the Pyrene box cages that allows at the same time to reduce a significant amount of disorder. In this highlight we discuss the recent developments of the encapsulation chemistry of the “Pyrene box” and the strategy behind its synthesis, together with further possible developments and the limitations of this biomimetic supramolecular cage system. The “Pyrene Box” shows great potential for future applications, ranging from fundamental studies of structure determination of unstable molecules to drug delivery vehicles.

Graphical abstract: Pyrene-box capsules for adaptive encapsulation and structure determination of unstable or non-crystalline guest molecules

Back to tab navigation

Publication details

The article was received on 01 Oct 2017, accepted on 19 Dec 2017 and first published on 19 Dec 2017


Article type: Highlight
DOI: 10.1039/C7CE01741C
Citation: CrystEngComm, 2018,20, 261-270
  •   Request permissions

    Pyrene-box capsules for adaptive encapsulation and structure determination of unstable or non-crystalline guest molecules

    D. G. Dumitrescu, W. Feng, Y. Legrand, A. van der Lee, E. Petit and M. Barboiu, CrystEngComm, 2018, 20, 261
    DOI: 10.1039/C7CE01741C

Search articles by author

Spotlight

Advertisements