A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

Abstract

Iridium complexes were used as a mitochondria-targeting agent to modify the surface of a photothermogenic nanozyme Fe₃O₄ nanoparticles (Ir@Fe₃O₄ NPs). Upon NIR irradiation, Ir@Fe₃O₄ NPs increase the localized temperature to 42 °C which accelerates the catalysis of ˙OH production from H₂O₂ resulting in excellent mild photothermal therapy.